Comorbidities Associated with Psoriasis: A Single Center Study of Morocco

Amani Fliti *

Department of Dermatology and Venerology, University Hospital Center Ibn Sina, University of Mohamed V, Rabat, Morocco.

Meryem Elomari Alaoui

Department of Dermatology and Venerology, University Hospital Center Ibn Sina, University of Mohamed V, Rabat, Morocco.

Narjess Er-Rachdy

Department of Dermatology and Venerology, University Hospital Center Ibn Sina, University of Mohamed V, Rabat, Morocco.

Karima Senouci

Department of Dermatology and Venerology, University Hospital Center Ibn Sina, University of Mohamed V, Rabat, Morocco.

Mariame Meziane

Department of Dermatology and Venerology, University Hospital Center Ibn Sina, University of Mohamed V, Rabat, Morocco.

*Author to whom correspondence should be addressed.


Abstract

Introduction: Psoriasis, a chronic autoimmune inflammatory disease, is recognized as a systemic inflammatory disease with cutaneous and extracutaneous manifestations, often associated with multiple comorbidities. Our study aims to identify the various comorbidities associated with psoriasis, determine their prevalence, and better understand the systemic nature of the disease in Moroccan patients

Materials and Methods: We conducted a prospective study in the dermatology department of the Ibn Sina University Hospital in Rabat, Morocco, between June 2021 and June 2022.  we included 150 patients who were diagnosed with mild, moderate, or severe psoriasis.

Results: 150 patients with psoriasis were enrolled during this period, with 77% cases of mild to moderate psoriasis and 23% of severe psoriasis. The sex ratio was 0.73, and the average age was 43.9 years. Comorbidities were dominated by metabolic syndrome (33.33%) in the lead, followed by autoimmune diseases (29.33%), cardiovascular diseases (24%), rheumatological diseases (18%), dermatological diseases (9%), or tumor pathologies (9%), infectious diseases (9%), smoking and alcohol consumption (9%), stress and psychiatric disorders (6%), and other diseases (6%).

Conclusion: This study encompasses the comorbidities associated with psoriasis in a Moroccan population. These comorbidities are diverse, with a predominant presence of metabolic syndrome, cardiovascular diseases, and thyroid disorders. A multicenter study involving a larger number of patients would be desirable.

Keywords: Psoriasis, comorbidities, metabolic syndrome, cardiovascular diseases


How to Cite

Fliti, A., Alaoui, M. E., Er-Rachdy, N., Senouci, K., & Meziane, M. (2024). Comorbidities Associated with Psoriasis: A Single Center Study of Morocco. Asian Journal of Research in Dermatological Science, 7(1), 39–43. Retrieved from https://journalajrdes.com/index.php/AJRDES/article/view/105

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References

Bu J, Ding R, Zhou L, Chen X, Shen E. Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review. Front Immunol. 2022;13:880201. DOI: 10.3389/fimmu.2022.880201. PMID: 35757712; PMCID: PMC9226890.

Benchikhi, Hakima et al. Étude PSOMAG : Prévalence des cas de psoriasis au Maghreb. Annales De Dermatologie Et De Venereologie. 2012;139: n. pag.

Mahil SK, Capon F, Barker JN. Update on Psoriasis Immunopathogenesis and Targeted Immunotherapy. Semin Immunopathol. 2016;38:11–27. DOI: 10.1007/s00281-015-0539-8

Rapp SR, Feldman SR, Exum ML, et al. Psoriasis causes as much disability as other major medical diseases. J Am Acad Dermatol. 1999;41(3Pt1):401–407. [PubMed: 10459113]

Lubrano E, Scriffignano S, Perrotta FM. Psoriatic Arthritis, Psoriatic Disease, or Psoriatic Syndrome? J Rheumatol. 2019;46(11):1428-1430. DOI: 10.3899/jrheum.190054. PMID: 31676545

Scarpa R. Psoriatic Syndrome or Psoriatic Disease? J Rheumatol. 2020 Jun 1;47(6):941. doi: 10.3899/jrheum.200051. Epub 2020 May 1. PMID: 32358159.

Gullvier.P, P soriasis et comorbidités cardiovasculaires et métaboliques, Annales de Dermatologie et de Vénéréologie,Volume 135, Supplement 6, 2008, Pages S301-S306, ISSN 0151-9638, Available:https://doi.org/10.1016/S0151-9638(08)75 481-4.

Takahashi H, Iizuka H. Psoriasis and metabolic syndrome. J Dermatol. 2012;39: 212–218.

Hao Y, Zhu YJ, Zou S, Zhou P, Hu YW, Zhao QX, Gu LN, Zhang HZ, Wang Z, Li J. Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions. Front Immunol. 2021;12:711060. DOI: 10.3389/fimmu.2021.711060 PMID: 34367173; PMCID: PMC8343100.

Wu JJ, Kavanaugh A, Lebwohl MG, Gniadecki R, Merola JF. Psoriasis and metabolic syndrome: Implications for the management and treatment of psoriasis. J Eur Acad Dermatol Venereol. 2022;36 (6):797-806. DOI: 10.1111/jdv.18044 Epub 2022 Mar 14. PMID: 35238067; PMCID: PMC9313585.

Toussirot E, Aubin F, Desmarets M, Wendling D, Augé B, Gillard J, Messica O, Guillot X, Laheurte C, Monnet E, Dumoulin G. Visceral adiposity in patients with psoriatic arthritis and psoriasis alone and its relationship with metabolic and cardiovascular risk. Rheumatology (Oxford).2021;60(6):2816-2825. DOI:10.1093/rheumatology/keaa720.PMID: 33232483.

Kashani A, Moludi J, Lateef Fateh H, Tandorost A, Jafari-Vayghan H, Dey P. Dietary Inflammatory Index in relation to psoriasis risk, cardiovascular risk factors, and clinical outcomes: a case-control study in psoriasis patients. Appl Physiol Nutr Metab. 2021 Dec;46(12):1517-1524. DOI: 10.1139/apnm-2021-0217

Epub 2021 Aug 4. PMID: 34348057.

Masson W, Lobo M, Molinero G. Psoriasis and Cardiovascular Risk: A Comprehensive Review. Adv Ther. 2020; 37(5):2017-2033. DOI: 10.1007/s12325-020-01346-6

Epub 2020 Apr 20. PMID: 32314303; PMCID: PMC7467489.

Woźniak E, Owczarczyk-Saczonek A, Placek W. Psychological Stress, Mast Cells, and Psoriasis-Is There Any Relationship? Int J Mol Sci. 2021;22(24): 13252. DOI: 10.3390/ijms222413252

PMID: 34948049; PMCID: PMC8705845.

Marek-Jozefowicz L, Czajkowski R, Borkowska A, Nedoszytko B, Żmijewski MA, Cubała WJ, Slominski AT. The Brain-Skin Axis in Psoriasis-Psychological, Psychiatric, Hormonal, and Dermatological Aspects. Int J Mol Sci. 2022;23(2):669. DOI: 10.3390/ijms23020669 PMID: 35054853; PMCID: PMC8776235.

Pezzolo E, Naldi L. The relationship between smoking, psoriasis and psoriatic arthritis. Expert Rev Clin Immunol. 2019;15 (1):41-48. DOI:10.1080/1744666X.20191543591 Epub 2018 Nov 6. PMID: 30380949

Wei J, Zhu J, Xu H, Zhou D, Elder JT, Tsoi LC, Patrick MT, Li Y. Alcohol consumption and smoking in relation to psoriasis: a Mendelian randomization study. Br J Dermatol. 2022;187(5):684-691. DOI: 10.1111/bjd.21718 Epub 2022 Aug 16. PMID: 35764530.

Napolitano M, Caso F, Scarpa R, Megna M, Patrì A, Balato N, Costa L. Psoriatic arthritis and psoriasis: differential diagnosis. Clin Rheumatol. 2016;35(8): 1893-1901. DOI: 10.1007/s10067-016-3295-9

Epub 2016 May 7. PMID: 27156076.

Eapi S, Chowdhury R, Lawal OS, Mathur N, Malik BH. Etiological Association Between Psoriasis and Thyroid Diseases. Cureus. 2021;13(1):e12653. DOI: 10.7759/cureus.12653 PMID: 33585138; PMCID: PMC7872875.

20-Hedin CRH, Sonkoly E, Eberhardson M, Ståhle M. Inflammatory bowel disease and psoriasis: modernizing the multidisciplinary approach. J Intern Med. 2021;290(2):257-278. DOI: 10.1111/joim

Epub 2021 May 4. PMID: 33942408.

Ungprasert P, Raksasuk S. Psoriasis and risk of incident chronic kidney disease and end-stage renal disease: A systematic review and meta-analysis. Int Urol Nephrol. 2018;50(7):1277-1283. DOI: 10.1007/s11255-018-1868-z Epub 2018 Apr 11. PMID: 29644523.

22-Fotiadou C, Lazaridou E. Psoriasis and uveitis: Links and risks. Psoriasis (Auckl). 2019;9:91-96. DOI: 10.2147/PTT.S179182 PMID: 31696050; PMCID: PMC6717847.