Clinical Overlap of Vitiligo and Psoriasis: A Histopathologically Confirmed Case Report
Pinzón Maira *
Hospital City "Dr. Enrique Tejera", Faculty of Health Sciences, University of Carabobo, Valencia, Venezuela.
Mejía katherin
Hospital City "Dr. Enrique Tejera", Faculty of Health Sciences, University of Carabobo, Valencia, Venezuela.
Endara Marcia
The Hospital City ́ ́"Dr. Enrique Tejera", University of Carabobo, Valencia, Venezuela.
Sandra Vivas
The Hospital City ''Dr. Enrique Tejera'', Valencia, Venezuela.
*Author to whom correspondence should be addressed.
Abstract
Vitiligo and psoriasis are highly prevalent chronic inflammatory dermatoses, usually described independently. Their concomitant presentation in the same patient represents a rare and clinically challenging entity. We report the case of a 50-year-old female patient with achromic macules in atypical locations (dorsum of both feet and the malleolar region), on which well-defined erythematous plaques with thick, adherent scales were observed. Both pathologies share immunological mechanisms mediated by T lymphocytes (Th1, Th17 in psoriasis; CD8+ in vitíligo) and proinflammatory cytokines (IL-17, IL-23, TNF-α e IFN-γ, CXCL10), which contribute to keratinocyte dysfunction and melanocytic destruction, respectively. The treatment was aimed at modulating the immune response using high-potency topical corticosteroids and calcineurin inhibitors (tacrolimus), with favourable evolution and partial repigmentation of the lesions.
Keywords: Psoriasis, vitiligo, autoimmunity, overlap syndrome, inflammasomes