A Case of Linear IgA Dermatosis in a Young Child

Main Article Content

V. Thadchanamoorthy
V. Vijayakanth
N. Thamilvannan


Diagnosis of Linear immunoglobulin A (IgA) bullous disease (LABD) is difficult as they present to relevant clinician late. This is the case of a 4-year-old Sri Lankan boy with a 2 months history of non-itching, blistering lesions on his extremities. Medical history was unremarkable. Medical treatments included a visit to a general practitioner, where he was treated with antibiotics unsuccessfully. We performed a skin biopsy and Direct immunofluorescent studies revealed a linear deposition of IgA antibody at the basement membrane. The clinical diagnosis of linear IgA dermatosis was established, with no eliciting cause. Resolution of blisters was achieved with oral prednisolone, dapsone and antibiotic treatment. This is the first case to our knowledge occurring in this age group with involvement of only extremities, sparing genital area.

Linear immunoglobulin a bullous disease, linear IgA dermatosis, dapsone, immunofluorescence

Article Details

How to Cite
Thadchanamoorthy, V., Vijayakanth, V., & Thamilvannan, N. (2020). A Case of Linear IgA Dermatosis in a Young Child. Asian Journal of Research in Dermatological Science, 3(2), 5-8. Retrieved from https://journalajrdes.com/index.php/AJRDES/article/view/30100
Case Study


Nantel-Battista M, Dhaybi RA, Hatami A, et al. Childhood linear IgA bullous disease induced by trimethoprim-sulfamethoxazole. Journal of Dermatological Case Reports 2010;4(3):33-5. DOI:https://doi.org/10.3315/jdcr.2010.1053

Oakley A. Linear IgA bullous disease. New Zealand: Hamilton; 2015.

Bowen JT. Six cases of bullous dermatitis following vaccination, and resembling dermatitis herpetiformis. Journal of Cutaneous Disease. 1901;19:401-23.

Nanda A, Dvorak R, Al-Sabah H, Alsaleh QA. Linear IgA bullous disease of childhood: an experience from Kuwait. Pediatric Dermatology 2006;23(5):443-7.

DOI:https://doi.org/10.1016/S01909622(88)70236-4 DOI:https://doi.org/10.1111/j.15251470.2006.002 79.x PMid: 17014638

Fortuna G, Marinkovich MP. Linear immunoglobulin A bullous dermatosis. Clinics in Dermatology. 2012;30(1):38-50.


Mark Tye Haeberle, William D James, et al Linear IgA dermatosis differential diagnoses, updated: Mar 06. 2020;30(1): 38-50. DOI:https://doi.org/10.1016/j.clindermatol.2011.03.008

Genovese G, Venegoni L, FanoniD, et al. Linear IgA bullous dermatosis in adults and children: A clinical and immunopathological study of 38 patients. Orphanet Journal of Rare Diseases. 2019;14:115.

DOI:https://doi.org/10.1186/s13023-019-1089-2. Lings K, Bygum A. Linear IgA bullous dermatosis: A retrospective study of 23 patients in Denmark. Acta dermato-venereologica. 2015;95(4):466-471.

Venning VA. Linear IgA disease: Clinical presentation, diagnosis, and pathogenesis. Dermatologic Clinics. 2011;29(3):453.