Preparation and Characterization of Natural Antioxidant Emulgels Loaded with Annona squamosa L. Extract with and without Penetration Enhancer

Main Article Content

Sidra Meer
Saira Aslam
Muhammad S. A. Abbasi
Muhammad Aslam Tahir

Abstract

Highly sustainable emulgels loaded with Annona squamosa L. extract with and without penetration enhancer were formulated. Characterization evaluations of prepared emulgels formulations were done at various storage conditions. Acetone (70%) was used to prepare Annona squamosa L. extract by using maceration technique. Emulgels were prepared by using 4% extract with and without penetration enhancer (clove oil 8%). Varying concentrations of carbapol 940 (0.5-2%) were used in the development of emulgels. All the formulations were kept first at 25°C and then stressed at 40°C to sort out the most stable formulation. The in vitro characterization of the optimized formulation was done including pH, conductivity, phase separation, and mean droplet size. These parameters were monitoring over a period of 90 days at 8°C, 25°C, 40°C and 40°C with 75 % RH.

Keywords:
Annona squamosa L., Emulgel, penetration enhancer, stability, droplet size.

Article Details

How to Cite
Meer, S., Aslam, S., Abbasi, M. S. A., & Tahir, M. A. (2020). Preparation and Characterization of Natural Antioxidant Emulgels Loaded with Annona squamosa L. Extract with and without Penetration Enhancer. Asian Journal of Research in Dermatological Science, 3(3), 1-10. Retrieved from https://journalajrdes.com/index.php/AJRDES/article/view/30106
Section
Original Research Article

References

Ribeiro AS, et al. Main benefits and applicability of plant extracts in skin care products. Cosmetics. 2015;2(2):48-65.

Aburjai T, Natsheh FM. Plants used in cosmetics. Phytotherapy Research. 2003; 17(9):987-1000.

Fowler JJ, et al. Innovations in natural ingredients and their use in skin care. Journal of Drugs in Dermatology: JDD. 2010;9(6 Suppl):S72-81,quiz s82-3.

Dubey N, Kumar R, Tripathi P. Global promotion of herbal medicine: India's opportunity. Current Science. 2004;86(1): 37-41.

Joshi B, et al. Emulgel: A comprehensive review on the recent advances in topical drug delivery. Int Res J Pharm. 2011;2(11): 66-70.

Kumar S, Singh N, Arora SC. Emulgel an Insight. European Journal of Pharmaceutical and Medical Research. 2015;2(4):693-698.

Haneefa KM, Mohanta GP, Nayar C. Emulgel: An advanced review. J. Pharm. Sci. & Res. 2013;5(12):254-258.

Hardenia A, Jayronia S, Jain S. Emulgel: An emergent tool in topical drug delivery. International Journal of Pharmaceutical Sciences and Research. 2014;5(5):1653.

Mariod AA, et al. Antioxidant activity of different parts from Annona squamosa, and Catunaregam nilotica methanolic extract. Acta Scientiarum Polonorum Technologia Alimentaria. 2012;11(3):249-258.

Sahz R, Pharmacognosy and pharma-cology of Annona squamosa: A review. Int J Pharm Life Sci. 2011;2(10): 1183-1189.

Gajalakshmi S, et al. Pharmacological activities of Annona squamosa: A review. International Journal of Pharmaceutical Sciences Review and Research. 2011; 10(2):24-29.

Ratshilivha N, et al. The variation in antimicrobial and antioxidant activities of acetone leaf extracts of 12 Moringa oleifera (Moringaceae) trees enables the selection of trees with additional uses. South African Journal of Botany. 2014;92: 59-64.

Mohamed MI, Optimization of chlorphenesin emulgel formulation. The AAPS Journal. 2004;6(3):81-87.

Vasiljević DD, et al. Rheological and droplet size analysis of W/O/W multiple emulsions containing low concentrations of polymeric emulsifiers. Journal of the Serbian Chemical Society. 2009;74(7): 801-816.

Zhang YJ. et al. Antioxidant phyto-chemicals for the prevention and treatment of chronic diseases. Molecules. 2015; 20(12):21138-21156.

Florence A, et al. Preliminary phytochemical studies of select members of the family Annonaceae for bioactive constituents. Biosci Discov. 2014;5(1):85-96.

Khan H, et al. Physical and chemical stability analysis of cosmetic multi-ple emulsions loaded with ascorbyl palmitate and sodium ascorbyl phosphate salts. Acta Poloniae Pharmaceutica. 2016;73(5): 1339-1349.

Johnsey Joseph DPA. Boby Johns George, Praveen Raj R, Noby Thomas, Betty Carla. Emulgel: A novel trend in topical drug delivery system. World Journal of Pharmaceutical And Medical Research. 2017;3(4):35-39.

Mahmood T, et al. Fabrication, physicochemical characterization and preliminary efficacy evaluation of a W/O/W multiple emulsion loaded with 5% green tea extract. Brazilian Journal of Pharmaceutical Sciences. 2013;49(2): 341-349.

Akhtar N, et al. Formulation and in vitro evaluation of a cosmetic emulsion containing apple juice extract. Asian Journal of Chemistry. 2010;22(9): 7235.

Mohsin S, et al. Formulation and stability of topical water in oil emulsion containing corn silk extract. Tropical Journal of Pharmaceutical Research. 2016;15(6): 1115-1121.

Herschel WH. The change in viscosity of oils with the temperature. Industrial & Engineering Chemistry. 1922;14(8):715-722.

Shahavi MH, et al. Clove oil nanoemulsion as an effective antibacterial agent: Taguchi optimization method. Desalination and Water Treatment. 2016;57(39):18379-18390.

Akhtar N, et al. Formulation development and pharmaceutical evaluation of aw/o emulsion of Coleus extract. Indian Journal of Pharmaceutical Education And Research. 2011;45(3):236-241.

Yang Y, et al. Formation and stability of emulsions using a natural small molecule surfactant: Quillaja saponin (Q-Naturale®). Food Hydrocolloids. 2013;30(2):589-596.

Dhanorkar V, et al. Development and characterization of rosin-based polymer and its application as a cream base. Journal of Cosmetic Science. 2002;53(4): 199-208.