Clinical Efficacy of Oral Terbinafine, Fluconazole and Itraconazole in the Treatment of Tinea Corporis
Published: 2018-09-14
Page: 32-41
Issue: 2018 - Volume 1 [Issue 1]
Walid Momin
Department of Pharmacy Practice, KLEU’s College of Pharmacy, Belagavi, Karnataka 590010, India
Divya Vupperla *
Department of Dermatology, Venereology and Leprosy, Government District Headquarters Hospital, Khammam, Telangana 507002, India
*Author to whom correspondence should be addressed.
Abstract
Context: Comparing terbinafine, fluconazole and itraconazole for its efficacy.
Aims: This study was aimed to assess the clinico-mycological efficacy of oral terbinafine, fluconazole and itraconazole in the treatment of tinea corporis in a tertiary care hospital.
Study Design: This is a randomised comparative study with a sample size of 60 patients.
Methods: Patients were enrolled after considering various inclusion and exclusion criteria into three groups. Group A (oral terbinafine 250 mg daily for 2 weeks), group B (fluconazole 150 mg once weekly for 4 weeks) and group C (itraconazole 200 mg once daily for 2 weeks). Clinical assessment was performed weekly on the basis of physician global assessment grading the severity of pruritus, erythematic, vesicle and desquamation.
Statistical Analysis Used: Fisher exact test was used to calculate the statistical significance between the pre and post interventional results.
Results: Of the 60 patients, 51 completed the study on a comparison between the three groups terbinafine (n=15), itraconazole (n=18) and fluconazole (n=18), it was observed that terbinafine was more effective on pruritis (80%), erythema (40%) and desquamation (80%). Itraconazole showed effectiveness on vesicle (66.66%).
Conclusions: Terbinafine was better than itraconazole and fluconazole in relieving signs and symptoms during the study period.
Keywords: Desquamation, erythema, fluconazole, itraconazole, terbinafine, tinea