Asian Journal of Research in Dermatological Science

Wells’ syndrome (WS) is an uncommon inflammatory dermatosis of unknown etiology which typically presents with pruritic cellulitis-like plaques on the extremities. The condition is thought to be a hypersensitivity reaction developing against a variety of exogenous and endogenous antigenic stimuli. Although the classic plaque type variant is the most common presentation, bullous, papulonodular, papulovesicular, granuloma-like, urticarial-like and fixed drug eruption types may be encountered as well. Histopathology is characterised by tissue eosinophilia, edema and flame figures. Treatment options include topical and systemic corticosteroids, topical calcineurin inhibitors, doxycycline, cetirizine, cyclosporine, tumor necrosis factor-α inhibitors and psoralen and long-wave ultraviolet light (PUVA). Here, we present a case of bullous WS responding to low-dose dapsone treatment