https://journalajrdes.com/index.php/AJRDES/issue/feed Asian Journal of Research in Dermatological Science 2024-04-24T11:50:16+00:00 Asian Journal of Research in Dermatological Science contact@journalajrdes.com Open Journal Systems <p style="text-align: justify;"><strong>Asian Journal of Research in Dermatological Science</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRDES/general-guideline-for-authors">Click here for Types of paper</a>) in all aspects of&nbsp;‘Dermatological Science’. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> https://journalajrdes.com/index.php/AJRDES/article/view/99 Dermatological Emergencies of a University Hospital Center of Rabat, Morocco 2024-03-18T09:40:13+00:00 Amani Fliti amanifliti2015@gmail.com Meryem Elomari Alaoui Mariame Meziane Nadia Ismaili Laila Benzekri Karima Senouci <p><strong>Introduction:</strong> Dermatological emergency is defined as any acute dermatological disorder that develops and worsens in less than 5 days. </p> <p><strong>Aims of Study:</strong> The aim of our study is to identify the main dermatological emergencies consultations, establish a demographic and clinical profile of the reasons for dermatological consultations, and review the various diagnostic and therapeutic difficulties encountered by interns and/or residents.</p> <p><strong>Materials and Methods: </strong>We conducted a prospective study in the dermatology department of the Ibn Sina University Hospital in Rabat between June 2022, and May2023. Excel and Statistical Package for the Social Sciences (SPSS Inc., version 15.0 for Windows) were used for data entry andanalysis. <strong>Results:</strong> 1,321 urgent dermatology consultations were received during this period. The sex ratio was 0.89, and the average age was 45.6 years (01months-95years). The reasons for consultation were: infectious pathologies in 47% (Erysipelas in the lead), inflammatory pathologies in 24%, toxidermia in 7%, autoimmune bullous dermatosis in 4%, tumor pathologies in 3%, and others in 15% of cases. 79 cases (5,9%) were hospitalized as emergencies and while the others (94,1%) only needed an ambulatory care.</p> <p><strong>Conclusion: </strong>The pathologies encountered in dermatological emergencies are very diverse dominated by infectious diseases. However, the majority of patients do not require an emergency consultation.</p> 2024-03-18T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrdes.com/index.php/AJRDES/article/view/100 The Use of Secukinumab in Psoriatic Patients: A Single Center Study in Morocco 2024-03-22T07:04:46+00:00 Meryem Elomari Alaoui elomarim077@gmail.com Amani Fliti Mariame Meziane Nadia Ismaili Laila Benzekri Karima Senouci <p><strong>Introduction</strong><strong>:</strong> Psoriasis is an immune cell-mediated inflammatory skin disease, characterized by the formation of scaly, indurated, erythematous plaques<strong>. </strong>Psoriasis comorbidities and symptoms affect the choice of treatments. Secukinumab is a fully human monoclonal anti-body that selectively neutralizes IL-17A and has proven to be effective in the treatment of multiple manifestations of psoriatic disease.</p> <p><strong>Materials and Methods</strong><strong>:</strong> In this prospective descriptive study of 13 patients with moderate to severe psoriasis in the Department of Dermatology at Ibn Sina University Hospital in Rabat between 2022 and 2024, we focus on the treatment of psoriasis with Secukinumab. All our patients received more than 6 injections of Secukinumab. Effectiveness was assessed using the change in absolute Psoriasis Area and Severity Index (PASI) score, and percentage of patients achieving PASI 75/90/100, at weeks 4 and 16.</p> <p><strong>Results</strong><strong>:</strong> In this study, 13 patients with severe psoriasis with a PASI&gt;10 were included. The mean age at diagnosis was 44.7 years and the mean duration of the disease before diagnosis was 5 years. All our patients received Secukinumab following this protocol (subcutaneous injection of 300mg at weeks 0,1,2,3 and 4, followed by 300mg every 4 weeks) and the PASI 75, PASI 90, PASI 100 was evaluated respectively.</p> <p>At week 4, 69.2% of patients still on Secukinumab had experienced at least a 50% reduction in PASI (PASI 50) from baseline. At week 16, the proportions of patients achieving PASI 75, PASI 90, and PASI 100 were: 23,1%, 30,7%, (46,2%) respectively.</p> <p>Adverse events possibly relevant to Secukinumab therapy were not reported in our patients</p> <p><strong>Conclusion</strong><strong>:</strong> To improve the quality of life of psoriatic patients, the choice of available treatments is now increasing. Secukinumab showed sustained effectiveness and favorable safety profile in patients with moderate to severe psoriasis in our patients.</p> 2024-03-22T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrdes.com/index.php/AJRDES/article/view/102 A Case Report about Coexistence of Pigmented Bowen’s Disease and Cutaneous Capillary Malformation: Unusual Case with Dermatoscopic Findings 2024-04-05T10:15:35+00:00 Meryem Elomari Alaoui elomarim077@gmail.com Amani Fliti Narjess Er-Rachdy Mariame Meziane Nadia Ismaili Laila Benzekri Karima Senouci <p>Capillary malformation and Bowen's disease (BD) or intraepidermal squamous cell carcinoma are two different entities whether clinically, histologically or prognostically.</p> <p>Bowen’s disease or squamous cell carcinoma in situ is a precursor malignant neoplasm restricted to the epidermis.</p> <p>Capillary malformations are cutaneous vascular anomalies caused by dysregulation of vascular channel formation during embryogenic development.</p> <p>The coexistence of a cutaneous capillary malformation with a skin malignancy is reported only once before by E.Bostan et al, that’s why we will present this case which associates these two entities: cutaneous capillary malformation and pigmented Bowen in the same location which has never been described.</p> 2024-04-05T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrdes.com/index.php/AJRDES/article/view/103 “Folliculitis Decalvans and Lichen Planopilaris” Phenotypic Spectrum: Report of Three Cases 2024-04-05T10:22:36+00:00 Amani Fliti amanifliti2015@gmail.com Meryem Elomari Alaoui Karrakchou Bamsa Azendour Hasna Senouci Karima Mariame Meziane <p><strong>Introduction:</strong> folliculitis decalvans (FD) and lichen planopilaris (LPP) are two primary cicatricial alopecias (neutrophilic and "lymphocytic," respectively) recently associated in a phenotypic spectrum. The "folliculitis decalvans and lichen planopilaris" phenotypic spectrum FDLPPPS is a combination of the clinical and histological features of FD and LPP. Our study aims to analyze three cases of a specific disease to better understand its clinical characteristics, evolution, and treatment.</p> <p><strong>Materials and Methods:</strong> We reported 3 cases of FDLPPPS with clinical manifestations, trichoscopy, histopathological features, treatments, and follow-up findings as a new presentation of this spectrum.</p> <p><strong>Results:</strong> We reported 3 cases; two females, and one male, with an average age of 33 years (ranging from 20 to 42 years). The average duration of disease evolution before diagnosis was 6.3 years (ranging from 1 to 10 years). Clinically, they presented with one or multiple alopecic patches on the vertex with pustules and crusts and a receding frontal hairline in one patient. Dermoscopy revealed signs consistent with lichen planopilaris and folliculitis decalvans. A diagnosis of phenotypic spectrum was established through histology. Patients received treatments including corticosteroids, antibiotics, hydroxychloroquine, or isotretinoin, with good improvement noted in one patient, moderate improvement in another, and stabilization in the third.</p> <p><strong>Conclusion:</strong> This phenotypic spectrum is a newly recognized entity that combines clinical and histological signs of FD and LPP. Early treatment is crucial to halt disease progression. The emergence of new variants within FDLPPPS, such as FD-frontal fibrosing alopecia, underlines the need for further case series to better characterize this spectrum.</p> 2024-04-05T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrdes.com/index.php/AJRDES/article/view/106 Sclerodermatomyositis Overlap Syndrome with Bullous Lesion: A Rare Presentation 2024-04-16T12:59:48+00:00 Meryem Elomari Alaoui elomarim077@gmail.com Amani Fliti Narjess Er-Rachdy Mariame Meziane Nadia Ismaili Laila Benzekri Karima Senouci <p>Overlap&nbsp;syndrome&nbsp;is diagnosed when at least two classical connective tissue diseases are observed in one patient, which develops simultaneously or sequentially.</p> <p>Sclerodermatomyositis (SDM) is one of the overlapping syndromes, defined by the association of dermatomyositis and scleroderma, which may be localized or systemic.</p> <p>The American College of Rheumatology European League against Rheumatism (ACR-EULAR) classification criteria are used to establish the diagnosis of systemic sclerosis and dermatomyositis.</p> <p>Clinically, this syndrome is characterized by the association of myalgia or myositis, arthralgia, with the skin changes of scleroderma, as well as Raynaud's phenomenon, interstitial lung disease, calcinosis, masked facies, dysphagia or esophageal dysmotility4, and immunologically, the presence of specific Pm/Scl antibodies in over 50% of cases.</p> <p>Rare cases in the literature have described this association, but not in its bullous form, which is why we report here on a patient with bullous sclerodermatomyositis.</p> 2024-04-16T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrdes.com/index.php/AJRDES/article/view/107 Pyoderma Gangrenosum: A Case Report 2024-04-24T11:50:16+00:00 Figilo Ibeinmo Moses figilomoses@yahoo.com Dasetima D. Altraide Amaewhule Mary Nnenda Amadi Ekechi Stella Ajirenike Rita Nkiru Chikeka Chimaroke Ukachi Ogbu Christian <p>Pyoderma Gangrenosum (PG) is an Uncommon Neutrophilic Dermatoses that presents as Auto-Inflammatory and Ulcerative Disorder of the Skin. It has an estimated incidence of 3-10 cases per million people per year. It is more common in the young and middle-aged people , average age of onset- 40-60years ,although it can affect children . It has female preponderance, and is characterized by painful papule, plaque or pustule that rapidly ulcerate with raised undermined borders on sites of normal or traumatized skin. It has no pathognomonic diagnostic test.</p> 2024-04-24T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrdes.com/index.php/AJRDES/article/view/105 Comorbidities Associated with Psoriasis: A Single Center Study of Morocco 2024-04-15T12:51:32+00:00 Amani Fliti amanifliti2015@gmail.com Meryem Elomari Alaoui Narjess Er-Rachdy Karima Senouci Mariame Meziane <p><strong>Introduction:</strong> Psoriasis, a chronic autoimmune inflammatory disease, is recognized as a systemic inflammatory disease with cutaneous and extracutaneous manifestations, often associated with multiple comorbidities. Our study aims to identify the various comorbidities associated with psoriasis, determine their prevalence, and better understand the systemic nature of the disease in Moroccan patients</p> <p><strong>Materials and Methods:</strong> We conducted a prospective study in the dermatology department of the Ibn Sina University Hospital in Rabat, Morocco, between June 2021 and June 2022.&nbsp; we included 150 patients who were diagnosed with mild, moderate, or severe psoriasis.</p> <p><strong>Results:</strong> 150 patients with psoriasis were enrolled during this period, with 77% cases of mild to moderate psoriasis and 23% of severe psoriasis. The sex ratio was 0.73, and the average age was 43.9 years. Comorbidities were dominated by metabolic syndrome (33.33%) in the lead, followed by autoimmune diseases (29.33%), cardiovascular diseases (24%), rheumatological diseases (18%), dermatological diseases (9%), or tumor pathologies (9%), infectious diseases (9%), smoking and alcohol consumption (9%), stress and psychiatric disorders (6%), and other diseases (6%).</p> <p><strong>Conclusion:</strong> This study encompasses the comorbidities associated with psoriasis in a Moroccan population. These comorbidities are diverse, with a predominant presence of metabolic syndrome, cardiovascular diseases, and thyroid disorders. A multicenter study involving a larger number of patients would be desirable.</p> 2024-04-15T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrdes.com/index.php/AJRDES/article/view/98 Determination of Dermatology Life Quality Index Criteria in Libyan Pemphigus Patients 2024-02-02T12:23:39+00:00 Hussein Osman Tarik Enaairi Ghait Alsdae Gamal Duweb drduweb@gmail.com <p><strong>Introduction:</strong> The term "pemphigus" describes a group of uncommon autoimmune dermatoses of the mucocutaneous membranes caused by acantholysis, or the breakdown of cell-to-cell adhesion, which can result in the production of potentially fatal bullae and erosion. Based on their unique clinical characteristics and pathogenesis, several subtypes of pemphigus illness have been discovered. These subtypes include paraneoplastic pemphigus (PNP), IgA pemphigus, pemphigus vulgaris (PV), and pemphigus foliaceus (PF).</p> <p><strong>Aim of the Study: </strong>To measure the Dermatology Life Quality Index (DLQI) in Libyan pemphigus patients and assess the impact of the disease on their lives.</p> <p><strong>Materials and Methods: </strong>In this descriptive study, 25 patients with pemphigus attending Bullous Clinic, dermatology department, Jumhoria Hospital, Benghazi, Libya, over one year from January to December 2021, were enrolled. All patients were registered in the clinic, and the diagnosis of pemphigus was confirmed by histopathology. For every patient, the DLQI score was measured by filling out the questionnaire.</p> <p><strong>Results:&nbsp; </strong>Of the 25 patients with pemphigus included in this study, 5 patients (20%) were male and 20 patients (80%) were female. The age ranged from 30 to 72 years, and the mean age was 43.64 years. The duration of the disease ranged from 1 to 408 months (mean: 83.12 months). Pemphigus folaiceous was encountered in 13 patients (52%). Concerning disease severity, 44% of cases presented with a severe illness. In 15 patients (60%), mucous membranes were not involved. Eight patients (32%) were treated with steroids (Prednisolone) and cytotoxic (Azathioprine) drugs. The mean DLQI scores for pemphigus vulgaris were 12.67 and for pemphigus folaiceous were 10.31. Dermatology Qualify Life Index (DLQI) scores showed a large effect on life quality in 56% of the study cases and a moderate effect in 32% of them.</p> <p><strong>Conclusion:</strong> Pemphigus has a substantial impact on Libyan patients' DLQI scores; individuals receiving systemic combination treatment were shown to have lower scores.</p> 2024-02-02T00:00:00+00:00 Copyright (c) 2024 Osman et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrdes.com/index.php/AJRDES/article/view/101 Clinical and Evolutionary Characteristics of Pemphigus by Gender: Comparative Study of 330 Cases 2024-03-30T07:44:38+00:00 Amani Fliti amanifliti2015@gmail.com Meryem Elomari Alaoui Mariame Meziane Nadia Ismaili Laila Benzekri Karima Senouci <p><strong>Introduction:</strong> Pemphigus is a group rare heterogeneous of intraepidermal autoimmune chronic bullous dermatoses associated with a high risk of morbidity and mortality. Despite its rarity, this condition persists as the most prevalent among bullous dermatoses in the Maghreb, including Morocco. Very few studies have investigated the significant influence of gender on the clinical phenotype, the activity score and the evolution of the disease. Our study objective is to analyze clinical and evolutionary characteristics of pemphigus based on gender differences.</p> <p><strong>Materials and Methods:</strong> A comparative retrospective descriptive study was conducted on 142 male and 188 female pemphigus patients treated at the “Department of Dermatology in Ibn Sina University Hospital, Rabat,” between 1990 and 2022. Data from medical records were analyzed, focusing on variables such as age at diagnosis, disease duration, medical history, presence of autoimmune conditions, clinical subtypes, extent of cutaneous and mucosal involvement, and disease progression. Data entry and analysis were performed using Excel and the Statistical Package for the Social Sciences.</p> <p><strong>Results:</strong> There were no significant differences in age, and both sexes had the same disease duration prior to diagnosis. The occurrence of pemphigus in women has been more closely associated with autoimmune diseases (25 cases compared to 2 cases in men). Regarding the phenotypes of pemphigus, pemphigus herpetiformis, pemphigus vegetans, and pemphigus vulgaris were more common in women. Isolated mucosal involvement was also more prevalent in women. Women exhibited a more severe Pemphigus Disease Area Index (PDAI) than men. In both male and female patients, the main treatment approach mainly involved oral corticosteroids, followed by an association of corticosteroids and cortisone-sparing agents. Azathioprine was the most frequently administered immunosuppressant (91.6%), with rituximab being used as the initial therapy in 8% of cases.</p> <p>Regarding disease progression, complete remission was noted in 83 women and 52 of men. No notable variances were observed in terms of bleaching time, relapse rates, or mortality.</p> <p><strong>Conclusion:</strong> Our findings suggest that gender might impact the clinical presentation of pemphigus patients. Specifically, we observed a higher prevalence of pemphigus herpetiformis, pemphigus vegetans, mucosal involvement, severe Pemphigus Disease Area Index (PDAI), and comorbid autoimmune diseases among women. However, our analysis indicates no significant disparities regarding disease progression or prognosis.</p> 2024-03-30T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrdes.com/index.php/AJRDES/article/view/104 Eosinophilia in Pemphigus: Single Center Study in Morocco 2024-04-05T11:38:37+00:00 Meryem Elomari Alaoui elomarim077@gmail.com Amani Fliti Mariame Meziane Nadia Ismaili Laila Benzekri Karima Senouci <p><strong>Introduction: </strong>Eosinophils, play major roles in the pathogenesis of various dermatoses (atopic dermatitis, bullous pemphigoid, drug reaction with eosinophilia and systemic symptoms (DRESS)…).</p> <p>Hypereosinophilia in pemphigus has not been well documented in the literature, hence we initiated this study with the aim of objectivizing this association and studying its characteristics.</p> <p><strong>Materials &amp; Methods:</strong> A retrospective comparative descriptive study was carried out in the dermatology department of Ibn Sina University Hospital, Rabat, between 1990 and 2023, on 391 patients with pemphigus. Data from medical records were analyzed, focusing on variables such as age at diagnosis, gender, duration of disease, medical history, presence of autoimmune conditions, clinical types, eosinophil count in the blood and presence of pruritus. Data entry and analysis were performed using Excel and Statistical Package for the Social Sciences.</p> <p><strong>Results:</strong> In this study, there were no significant age or gender differences. Hypereosinophilia was observed in 13,3% of patients with pemphigus, and for the clinical phenotypes, pemphigus vulgaris was more frequent, followed by pemphigus seborrheic. The majority of these patients had associated pruritus. In terms of disease progression, the hypereosinophilia was resolved in the majority of our patients after therapeutic management of pemphigus.</p> <p><strong>Conclusion:</strong> To further understand the implications of eosinophils in the pathogenesis and clinical manifestations of various pemphigus subtypes, additional research is warranted. and for the hypereosinophilia resolved with treatment of pemphigus</p> 2024-04-05T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.