Open Access Case Study

The use of Cryotherapy and Albendazole as a Beneficial Cutaneous Larva Migrans Therapy: A Case Report

Frieda Yanuar, Bobby Febrianto, Eka Devinta Novi Diana, Alfina Rahma, Harijono Kariosentono, Rafael Bagus Yudhistira

Asian Journal of Research in Dermatological Science, Page 1-7

Aims: To describe the effect of combination albendazole and cryotherapy as a spesific CLM therapy.

Presentation of case: A 21-year-old man reported a winding reddish patches that felt itchy and hot since 1 month ago. Erythema papules and hyperpigmented patches and hyperpigmented macules in the serpiginous form were found at right brachial, right genu, and right cruris regions. The patient was given albendazole therapy 1x400 mg for 3 days orally and mixed cream (albendazole 400 mg, mupirocin, and clobetasol propionate) for 7 days showed only minimal clinical cure. For optimal results, we combine albendazole therapy with cryotherapy with liquid nitrogen. Combination therapy resulted in satisfactory improvement and no recurrences after therapy.

Discussion: The first-line therapy for the treatment of CLM cases is ivermectin 0.15-0.2 mg / kg / day and second-line albendazole 400 mg given for 3 consecutive days. Alternative therapy such as cryotherapy in an unsuccessful case with oral therapy and also to prevent recurrency.

Conclusion: Administration of albendazole combination therapy with cryotherapy using liquid nitrogen as management of CML therapy is effective in unsuccessful case to oral therapy.

Open Access Case Study

Severe form of Dress Syndrome Treated with Bolus Corticotherapy

J. B. Ntihebuwayo, F. Hali, F. Z. El Fatoiki, S. Chiheb

Asian Journal of Research in Dermatological Science, Page 14-18

Drug hypersensitivity syndrome or DRESS is a drug reaction with eosinophilia and systemic symptoms. The prescription of systemic corticosteroids has been proposed in case of visceral involvement with the possibility of corticosteroid bolus in the presence of severe signs of DRESS. We report the case of a patient who developed DRESS syndrome two months after taking Mesalazine and fifteen days after taking Sulfasalazine with moderate hepatic impairment which progressed to severe hepatic cytolysis despite the discontinuation of the incriminating treatment and the introduction of low-dose corticosteroid therapy. The administration of bolus corticosteroids for three days followed by oral corticosteroids allowed the control and the clinical and biological improvement of the disease.

Open Access Case Study

Caricature of Ageing- A Case Report and Review of Literature of Werner Syndrome

Farhana Tahseen Taj, Anisha Bindagi

Asian Journal of Research in Dermatological Science, Page 19-22

Werner’s Syndrome (WS) also known as Pangeria   is a rare premature aging autosomal recessive disorder. It affectes the connective tissue throughout the body with high prevalence in Sardinia and Japan.The signs of premature aging appears by second to third decade of life with  increased risk of malignancies and atherosclerosis .The clinical features include characteristic aged appearance which  typically begins to develop in their twenties which  includes graying and loss of hair, a hoarse voice, scleroderma like skin changes. Patients have characteristic facial appearance described as “bird-like facies.”

We present a case of a 43 year old male who was misdiagnosed and treated as a case of scleroderma previously. We have been motivated to report our case with Werner syndrome because he was very similar to scleroderma in terms of physical findings.

Open Access Case Study

Granulomatous Cheilits: A Rare Entity

Farhana Tahseen Taj, Srujana Adabala

Asian Journal of Research in Dermatological Science, Page 23-26

Granulomatous cheilitis (GC) also known as Miescher cheilitis, is a rare chronic inflammatory idiopathic disorder of lips characterized by painless swelling of lips and was first described by Meischer in 1945. Wiensenfeld described it as non caseating granulomatous inflammation without any systemic cause and termed it as Oro facial granulomatosis (OFG). We hereby wish to present this rare entity, the mode of presentation and its various treatment modalities.

Open Access Short Communication

The Minus One Rule of Hairwash in Monsoon

Harsimran Kaur, Priya Puja, Sushant Shetty

Asian Journal of Research in Dermatological Science, Page 8-13

Aims: The Asian subcontinent has a well-defined monsoon season; however, it is still uncertain whether hair loss increases during the monsoon. Scant literature is available on correlation between hair wash frequency and hair loss. This small cross-sectional study aimed to objectively assess whether patients perceived increased hairfall during monsoons. In addition, we aimed to formulate a hairwash frequency schedule to help in reducing seasonal hairfall in monsoon.

Study Design: Cross-sectional study

Place and Duration of Study: Kaya Skin Clinics, New Delhi, India. The Study was conducted from August 2020 till September 2020

Methodology: After due consent, 25 females who were experiencing hairfall and not taken any hair salon treatment in the last 3 months were enrolled during the months of August and September. Patients with medical comorbidities and other hair disorders were excluded.  A new concept by the name of “minus 1 rule” was formulated where 1 implied 24 hours.  A hairwash schedule based on this concept was given for four washes. Hair shed during each wash were collected and a validated Hair Shedding Visual Scale based on hair length was used by the principal investigator to score the samples.

Results: Seventy six percent experienced maximum hairfall in monsoon. The mean Hair shedding Visual Scale scores at baseline and the third wash were 5.24±1.82 and 4.32±1.76 respectively and this difference in mean scores was statistically significant (P value <0.00001).  

Conclusion: This study found a statistically significant reduction in hair fall visual scale scores with a hairwash 24 hours prior to the need for a wash during the monsoon season. In addition, we found that majority females reported hairloss during the monsoon season. To the best of our knowledge, this is the first study which has attempted to find a relation between hair wash frequency and hair loss during the monsoon season.